Effect of interventional treatment on the expression of E-cadherin in bladder cancer
10.3969/j.issn.1002-1671.2015.07.030
- VernacularTitle:介入治疗对膀胱癌组织上皮钙黏附素表达的影响
- Author:
Hongxing ZHAO
;
Yufeng QIAN
;
Rongjiang WANG
;
Sihai SHAO
;
Wenjuan ZHU
- Publication Type:Journal Article
- Keywords:
bladder tumor;
interventional;
E-cadherin
- From:
Journal of Practical Radiology
2015;(7):1178-1181,1185
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions of E-cadherin (E-cad)in arterial chemoembolization interventional therapied bladder carcinoma.Methods The expressions of E-cad in bladder tumor tissues of30 non-muscle-invasive bladder carcinoma treated with preoperative interventional chemotherapy and 20 invasive bladder carcinoma treated with surgical were measured by streptavi-din-peroxidase immunohisto chemical method.The changes of E-cad expression in bladder carcinoma before and after interventional treatment were analyzed.Results The averaged normal expressions rate of E-cad in non-muscle-invasive and muscle invasive bladder carcinoma was 70.0% (21/30),25.0% (5/20)respectively.The averaged normal expressions rate of E-cad after interventional treatment was improved to 90% (27/30),the differences were statistically significant (P <0.05 ).Conclusion The expressions of E-cad in bladder carcinoma had significant relations with pathological grade and clinical stage.The abnormal expressions of E-cad in the mucosal surface, may be associated with inflammation.Interventional treatment can significantly improve the expressions of E-cad of tumor tissue and delay the progress of bladder cancer.
