Determination of Chloride and Sulfate in Lithium Carbonate Crude Drug by Ion Chromatography
- VernacularTitle:离子色谱法测定碳酸锂原料药中的氯化物及硫酸盐
- Author:
Guilian XU
;
Xin GENG
- Publication Type:Journal Article
- Keywords:
Ion chromatography;
Lithium carbonate crude drug;
Chloride;
Sulfate
- From:
China Pharmacist
2015;(2):324-325,326
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To establish a method for the determination of chloride and sulfate in lithium carbonate crude drug by sup-pressed ion chromatography. Methods:The analysis column and the guard column was Thermo IonPac AS11(250 mm × 4 mm) and IonPac AG 11(50 mm ×4 mm), respectively. Potassium hydroxide solution(10 mmol·L-1) generated by an eluent generator(EG) was used as the eluent at a flow rate of 1. 0 ml·min-1 . And the temperature of column and conductivity cell was 30℃ and 35℃, re-spectively. The suppressor electric current was 36 mA, and the injection volume was 10 μl. Results:The linear range of chloride ion and sulfate ion was 1. 0-20μg·ml-1 with r of 0. 995 1 and 0. 997 3,respectively, and the recovery was 106. 6%(RSD=2. 6%,n=6) and 100. 3%(RSD=1. 9%,n=6), respectively. Conclusion:The method is accurate and reliable, and can be used in the determina-tion of chloride and sulfate in lithium carbonate crude drug.
