Relationship between serum cystatin C concentration and corornary lesions in patients with coronary heart disease
10.3969/j.issn.1671-8348.2015.04.015
- VernacularTitle:冠心病患者血清胱抑素C水平与冠状动脉病变程度相关性分析
- Author:
Jun WANG
;
Bangning WANG
;
Ancai WANG
;
Ming WU
;
Deguo WANG
- Publication Type:Journal Article
- Keywords:
coronary disease;
serum cystatin C;
coronary arterial lesions;
Gensini score
- From:
Chongqing Medicine
2015;(4):475-477,481
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the changes of serum cystatin C(Cys C) in patients with coronary heart disease(CHD) and normal kidney function ,and evaluate the predictive value of Cys C concentration on coronary arterial lesions .Methods Serum levels of Cys C were detected in 316 patients with coronary heart disease and normal renal function .The relationship between serum 1evels of Cys C and coronary heart disease was evaluated from three aspects :the number of diseased vessels ,the severity of diseased ves‐sels and the CHD Gensini scores .Results The Cys C level in CHD group was significantly higher than that of non‐CHD group [(1 .24 ± 0 .32)mg/L vs .(1 .12 ± 0 .27)mg/L ,P<0 .01] .Serum Cys C was significantly higher in the multi‐vessel disease group than that of the single‐vessel disease group[(1 .31 ± 0 .31)mg/L vs .(1 .20 ± 0 .32)mg/L ,P<0 .01] .Serum Cys C was significantly higher in the severe coronary artery stenosis group than in the mild stenosis group [(1 .29 ± 0 .36)mg/L vs .(1 .16 ± 0 .23)mg/L , P<0 .01] .Cys C was positively correlated with the Gensini scores of coronary arterial lesion (r=0 .195 ,P<0 .01) .Conclusion Cys C levels increased in patients with coronary heart disease and normal renal function .Cys C was positively correlated with the Gensini scores of coronary arterial lesion .Serum Cys C levels has certain predictive value on coronary arterial lesions in patients with CHD .
