Performance of different GFR equations for estimating glomerular filtration rate among professional population
10.3969/j.issn.1671-8348.2015.06.029
- VernacularTitle:不同肾小球滤过率估计公式对体检人群肾功能的评价
- Author:
Jing ZHANG
;
Guisen LI
;
Yuping LIU
;
Li WANG
- Publication Type:Journal Article
- Keywords:
glomerular filtration rate;
renal function;
serum creatinine
- From:
Chongqing Medicine
2015;(6):798-800,803
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the performance of different GFR equations in estimating renal function of people undertake health examination.Methods A total of 8 476 occupational physical examination population were selected.Serum creatinine,urea nitrogen,serum cystatin and urine routine of all cases were collected to be used to calculate eGFR through different GFR equations of the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI)equation.,the equation based on cystatin C(Cys-EPI),the combined creatinine-cystatin C equation(CC-EPI),simplified MDRD equtation (a-MDRD),modified eGFR equation for Chinese pa-tients (c-MDRD).Results There was a significant correlation among physical examination population using different GFR equa-tions calculated results(P <0.01).But comparisons the means of eGFR calculated by different equations are statistical significant (P <0.01).Comparing with CKD-EPI,the eGFR calculated by c-MDRD is higher(P =8.7×10-263 ).The ratios of population,eG-FR<60 mL·min-1 ·1.73(m2 )-1 by different equations,have significant difference (P <0.01).And the ratio difference is more concentrated in the range Of 45-59 mL·min-1 ·1.73(m2 )-1 .Devide the populations into two groups,which are chronic kidney disease (CKD)and Non-CKD according to the standard of eGFR and Urine protein by CKD-EPI.Among CKD,the eGFR calculated by Cys-EPI,CC-EPI,c-MDRD are higher;but among non-CKD group,eGFR calculated by Cys-EPI,a-MDR are lower,the eGFR of c-MDRD is significantly higher,while the result of CC-EPI is most close to the CKD-EPI.Conclusion There were significant corre-lations between the different equations to calculate GFR among physical examination population.
