Clinical significance of CXCL9 expression in peripheral blood of patients with systemic lupus erythematosus

VernacularTitle:系统性红斑狼疮患者外周血CXCL9表达水平及其临床意义
Author: Xiaoyan YE ; Yongjiang DAI ; Bingxin MENG ; Yuanzhi WANG ; Xiongan LIANG
Publication Type:Journal Article
Keywords: lupus erythematosus,systemic; chemokine; CXCL9; peripheral blood
From: Chongqing Medicine 2015;(5):655-656,659
CountryChina
Language:Chinese
Abstract: Objective To investigate the expression and significance of CXCL 9 in systemic lupus erythematosus (SLE ) . Methods The level of CXCL9 in peripheral blood from 20 patients with SLE and 20 normal controls were measured by enzyme linked immunosorbent assay .Compare the difference of the expression level of CXCL 9 in peripheral blood between two groups and analyzed their correlation with ages ,duration ,SLE diseases activity index (SLEDAI) .Results The level of CXCL9 in peripheral blood in patients with systemic lupus erythematosus was (1 549 .14 ± 362 .74)pg/L ,but in normal controls was(602 .54 ± 83 .70)pg/L .The level of CXCL9 in peripheral blood in patients with systemic lupus erythematosus was obviously higher than that in controls by statistical analysis ,there was significant difference between the two groups (P<0 .01) .The expression level of CXCL9 in pe‐ripheral blood of patients with systemic lupus erythematosus was positively correlated with SLEDAI (r=0 .892 ,P<0 .01) .Conclu‐sion CXCL9 may be involved in the pathogenesis of systemic lupus erythematosus .