Comparison of the efficacy and safety of Xuezhikang and fluvastatin for mild liver function abnormalities in the very elderly patients with angina pectoris
10.3760/cma.j.issn.1008-6706.2015.06.017
- VernacularTitle:血脂康与氟伐他汀对轻度肝功能异常老年心绞痛患者的安全性比较
- Author:
Mingyi WANG
;
Yujing ZHANG
;
Jian XU
;
Xinbin YANG
;
Feng FENG
- Publication Type:Journal Article
- Keywords:
Xuezhikang;
Fluvastatin;
Liver diseases;
Angina pectoris;
Aged
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;(6):851-852,853
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the efficacy and safety of the treatment of Xuezhikang and fluvastatin in elderly angina patients with mildly abnormal liver function .Methods 84 cases of ALT in 40-80u/L very elderly patients with coronary heart disease were randomly selected and divided into the two groups , the Xuezhikang group received Xuezhikang (0.6g,bid,orally),the fluvastatin group received fluvastatin (40mg,1time/night,oral),the total course was 12weeks,the TC,TG,LDL-C,HDL -C were measured before and after treatment ,liver function was measured once 2 -4times.If ALT was 3 times higher than before , Xuezhikang was instead of statins , if ALT was 5 times higher than before ,both of the two drags were withdrawaled .Results The TC,LDL,TG,HDL-C and ALT of the two groups were no significant difference before treatment (P >0.05),the TC,LDL,TG were decreased after treatment in the both group .There was no case of increased of ALT to three times in Xuezhikang group ,however ,ALT of 6 patients were increased more than three times in fluvastatin group ,four weeks after exchange of Xuezhikang ,the ALT were not continued to rise .Conclusion Both the two medicine can significantly lowered the cholesterol in very elderly patients with angina ,but the Xuezhikang were more safety in the patient with mild increased of liver function .
