Effects of Jiuxieling Granules on IL-1, IL-6, TNF-α, and IFN- γ in Rats with Spleen Kidney Yang Deficiency Ulcerative Colitis
10.3969/j.issn.1005-5304.2015.017
- VernacularTitle:久泻灵颗粒对脾肾阳虚型溃疡性结肠炎大鼠相关细胞因子的影响
- Author:
Yaqing XU
;
Hailong LI
;
Jiaquan QIU
;
Yuxin JIA
;
Xiaoli CHENG
;
Haixia MING
;
Yonglin LIANG
;
Yuhong WU
- Publication Type:Journal Article
- Keywords:
Jiuxieling Granules;
ulcerative colitis;
spleen and kidney yang deficiency;
IL-1;
IL-6;
TNF-α;
IFN-γ;
rats
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2015;(4):59-61,62
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect mechanism of action mode of Jiuxieling Granules in spleen and kidney yang deficiency ulcerative colitis. Methods The perfusion of Rhei Radix et Rhizoma Decoction plus intramuscular injection of hydrocortisone and combined with TNBS and ethanol enema were employed to establish UC animal model. Ninety rats were randomly divided into blank group, model group, SASP group and Jiuxieling Granules 7 days, 14 days and 21 days groups. All treatment groups received relevant medicine intervention. The levels of IL-1, IL-6, TNF-α, and IFN-γin serum and colon tissue were detected by ELISA. Results Compared with the blank group, the levels of IL-1, IL-6, TNF-α, and IFN-γ in serum and colon tissues of rats in model group increased (P<0.05);compared with the model group, the levels of IL-1, IL-6, TNF-α, and IFN-γin serum and colon tissues of rats in treatment groups were reduced greatly (P<0.05), among which Jiuxieling Granules 21 days group showed the most obvious effects (P<0.05). Conclusion Jiuxieling Granules can regulate the normal secretion of the levels of IL-1, IL-6, TNF-α, and IFN-γin serum and colon tissue of model rats, and inhibit inflammation and protect colonic mucosa.
