The efficacy and safety of tranexamic acid in patients undergoing off-pump coronary bypass grafting:a systematic review and meta-analysis
10.3969/j.issn.1671-8348.2015.09.026
- VernacularTitle:氨甲环酸在非体外循环冠脉移植手术中应用效果与安全性的系统评价
- Author:
Juntao FU
- Publication Type:Journal Article
- Keywords:
tranexamic acid;
off-pump coronary artery bypass grafting;
OPCAB;
meta-analysis;
systematic review
- From:
Chongqing Medicine
2015;(9):1232-1234,1238
- CountryChina
- Language:Chinese
-
Abstract:
Objective The aim of this study is to evaluate the efficacy and safety of tranexamic acid for patients undergoing off-pump coronary bypass grafting .Methods The MEDLINE ,Embase were searched for randomized controlled trials(RCTs) of patients undergoing off-pump coronary bypass grafting .And the Cochrane Collaboration′s RevMan 5 .2 software was used to evalu-ate the quality of the included studies and to perform the meta-analyses .Results 10 trials involving 851 patients were included . Tranexamic acid significantly reduced the postoperative blood loss (24 h:SD= -208 .41 ,95% CI:-311 .48 - -105 .35 ,P<0 .000 1) ,overall risk of allogeneic blood component transfusion(RR=0 .47 ,95% CI:0 .33 -0 .66 ,P< 0 .000 1) ,and packed red blood cell transfusions(RR=0 .60 ,95% CI:0 .49-0 .74 ,P<0 .001) .But no association was found between tranexamic acid and ad-verse thrombotic events .Conclusion Tranexamic acid significantly reduced the postoperative blood loss and overall risk of allogene-ic in patients undergoing OPCAB .However ,due to the limited quality of the included studies ,further evidence with more high quali-ty studies is still needed .
