Effect of Miacalcic Combined with Calcium in the Treatment of Osteoporosis and Influence on Bone Metab-olism Index
- VernacularTitle:鲑鱼降钙素联合钙剂治疗骨质疏松的疗效及对骨代谢相关指标的影响观察
- Author:
Zhao JIE
;
Yuan YI
;
Jiang GUOQIANG
- Publication Type:Journal Article
- Keywords:
Miacalcic;
Compound calcium carbonate;
Osteoporosis;
Bone metabolism
- From:
China Pharmacist
2015;(3):429-430,436
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the clinical efficacy of salmon calcitonin combined with calcium in the treatment of osteoporosis and the effect on bone metabolism index. Methods:Totally 360 cases of patients with osteoporosis were randomly divided into the ob-servation group and the control group with 180 ones in each. The patients in the control group were given compound calcium carbonate tablets, po, qd, and those in the observation group were given 50IU salmon calcitonin injection additionally, im, qd. After two months of treatment, the changes in pain score, bone density and bone metabolism related indicators of the two groups were compared before and after the treatment. The clinical efficacy and adverse reactions of the two groups were observed as well. Results: After the treat-ment, both groups showed lower pain scores (P<0. 01) when compared with those before the treatment, and the reduction in the ob-servation group was more significant than that in the control group. After the treatment, the bone density had no significant change in the two groups(P>0. 05). The bone metabolism parameters including serum BGP,β-CTX, PTH, BNALP and 25OHVitD were signif-icantly improved when compared with those before the treatment (P<0. 01), and the improvement in the observation group was better than that in the control group (P<0. 01). The incidence of adverse reactions in the observation group was significantly higher than that in the control group (P<0. 01). Conclusion:Salmon calcitonin combined with calcium can significantly improve the efficacy in the treatment of osteoporosis with improved pain scores and bone metabolism related indicators, and the combination is much better than calcium alone, however, the adverse reactions are significantly increased.
