Investigation about atorvastatin resist to tobacco smoking inducing endothelial inflammation

VernacularTitle:阿托伐他汀抵抗吸烟相关性血管内皮损伤的实验研究
Author: Yi GUO ; Xiaogang LU ; Yuanbin DAI
Publication Type:Journal Article
Keywords: vascular cell adhesion molecule-1; E-selectin; smoking; atorvastatin; human umbilical vein endothelial cells
From: Chongqing Medicine 2015;(19):2616-2617,2620
CountryChina
Language:Chinese
Abstract: Objective To explore the role of atorvastatin resist to tobacco smoking inducing endothelial inflammation .Meth‐ods HUVECs were divided into normal control group ,cigarette smoking extract(CSE) group and atorvastatin(AS)+CSE group . The cellular morphology of HUVECs in three group were observed ,then the expressions of VCAM‐1 and E selectin in HUVECs in three group were detected by western blot assay .Results In CES group ,drastic morphological change of HUVECs were observed . In AS+CSE group ,minor morphological change of HUVECs were observed .Also ,the protein levels of VCAM‐1 and E selectin were much higher in CSE group than that of in other two groups(P<0 .05) ,and the protein levels of VCAM‐1 and E‐selectin in AS+CSE group were a little higher than that of in control group ,but much lower than that of in CSE group(P<0 .05) .Conclusion Our results showed that atorvastatin might partly resist to tobacco smoking inducing endothelial inflammation .