Regulating autonomic nerve system:a new field of anti-inflammatory therapy for cardiovascular diseases
10.3969/j.issn.1000-4718.2015.02.033
- VernacularTitle:调节自主神经系统:心血管疾病抗炎治疗的新领域
- Author:
Dufang MA
;
Ping JIANG
;
Jinlong YANG
;
Xiao LI
- Publication Type:Journal Article
- Keywords:
Autonomic nervous system;
Cholinergic anti-inflammatory pathway;
Sympathetic nervous system;
Vagus nerve;
Cardiovascular diseases;
Inflammation
- From:
Chinese Journal of Pathophysiology
2015;(2):374-378,384
- CountryChina
- Language:Chinese
-
Abstract:
The role of chronic inflammation and autonomic neuropathy in the crucial underlying process con -tributing to the initiation and the progression of various cardiovascular diseases is well established .It is well known that the immune system is innervated by the autonomic nervous system , and the inflammatory reaction and immune reaction are re-gulated by the autonomic nerve system .Vagus nerve depresses inflammatory reaction via cholinergic anti-inflammatory path-way (CAP), while sympathetic nervous system has bidirectional regulation of pro-inflammation and anti-inflammation, which are affected by several factors such as the concentration of neurotransmitters or types of receptors .In this paper , we reviewed different effects of CAP and sympathetic nervous system on cardiovascular inflammatory reaction .Activation of CAP and regaining normal sympathetic function will improve the chronic inflammation in the process of cardiovascular disea -ses.Low-toxic and selective α7nAchR agonist is expected to be applied in cardiovascular diseases to alleviate chronic in -flammation .
