Correlation between expression of Ki-67 and Her-2 and clinical features in breast invasive ductal carcinoma
10.7644/j.issn.1674-9960.2015.02.015
- VernacularTitle:Ki-67、Her-2在乳腺浸润性导管癌中的表达与临床特征相关性研究
- Author:
Chen LI
;
Shujuan JIN
;
Xiaojing LIU
;
Xiaowei HAN
;
Xiaopeng HAO
;
Hanmin PANG
;
Yan HUANG
- Publication Type:Journal Article
- Keywords:
Ki-67;
Her-2;
breast neoplasms;
clinical features
- From:
Military Medical Sciences
2015;(2):140-142,146
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the correlation between the expression of Ki-67 and Her-2 and clinical features in breast invasive ductal carcinoma .Methods Clinical and pathological data of 202 female breast invasive ductal carcinoma patients were collected between January 2012 and September 2014 .The correlation between the expression of Ki-67 and Her-2 and clinical features was analyzed .Results The positive rate of Ki-67 was 73.3%(148/202) and that of Her-2 was 19.3(39/202).The expression of Ki-67 was related to histological grading , ER and PR status(P<0.05),but not to age, tumor size or lymph node status(P>0.05).The expression of Her-2 was related to ER and PR status (P<0.05), but not to age, tumor size, histological grading, or lymph node status(P>0.05).Moreover, the low expression Ki-67 and negative expression of Her-2 were positvely corelated with the positive expression of hormone receptor [estrogen receptor(ER),pro-gestin receptor(PR)](P<0.05).Conclusion High expression of Ki-67 suggested that the differential grade of tumor was lower , malignant grade was higher , infiltration was stronger and metastasis was easier .High expression of Ki-67 and positive Her-2 suggests lower sensitivity to endocrine therapy and treatment .Detection of Ki-67 and Her-2 expression in breast inva-sive ductal carcinoma is of guiding significance for understanding the degree of malignancy and for evaluating prognosis .
