Lymphocyte infusion with lymphoma and leukemia immunotherapy
10.3760/cma.j.issn.1009-9921.2010.05.001
- VernacularTitle:淋巴细胞输注与淋巴瘤和白血病免疫治疗
- Author:
Ping ZHU
;
Chunrong TONG
;
Haizhou XING
- Publication Type:Journal Article
- Keywords:
Leukemia;
Lymphoma;
Lymphocyte transfusion;
TCR gene transfer;
Child-maternal microchimerism
- From:
Journal of Leukemia & Lymphoma
2010;19(5):257-259,261
- CountryChina
- Language:Chinese
-
Abstract:
Remarkable achievements have been made for lymphocyte infusion of lymphoma and leukemia, especially of lymphoproliferative disease within twenty-first century. The donor lymphocyte infusion or mobilized donor lymphocyte infusion (DLI/DSI) offer an opportunity of second remission for relapse patients post-transplantation. Cytokine-induced killer/DC cytokine-induced killer play an anti-tumor activity beyond non-MHC restricted. Cytotoxic lymphocyte infusion activated by synthetic tumor antigen produces targeted effects of anti-tumor. Transgenic CTL of anti-tumor TCR has brought the dawn in lymphoma and leukemia patients with defective lymphocytes. Maternal lymphocyte infusion play an anti-tumor/viral activity by avoiding the immune barrier of HLA mismatch.
