Optimal therapy of advanced Hodgkin' s lymphoma
10.3760/cma.j.issn.1009-9921.2012.02.002
- VernacularTitle:进展期霍奇金淋巴瘤的理想治疗方案
- Author:
Yi LI
;
Xiaoyan KE
- Publication Type:Journal Article
- Keywords:
Hodgkin's lymphoma;
Advanced;
Chemotherapy
- From:
Journal of Leukemia & Lymphoma
2012;21(2):68-69,76
- CountryChina
- Language:Chinese
-
Abstract:
Advanced-stage Hodgkin's lymphoma (HL) has become a curable disease in the majority of patients.ABVD is considered to be the standard therapy,but debates continue regarding the role of radiation therapy(RT)in this patient population. The incorporation of interim positron emission tomography (PET) imaging, and characterization of HL on cellular and molecular levels are emerging as tools for treatment stratification and predictors of disease status. Therapeutic advances over the past 3 decades have resulted in the cure of the majority of the patients with advanced-stage HL.Several questions have emerged when considering what constitutes optimal therapy with a balance between a high cure rate and minimizing shortand long-term toxicity.This review focuses on 3 key elements:what is the optimal chemotherapy? What is the role of radiation therapy(RT)in advanced HL? Can therapy based on clinical biological risk factors be adapted?
