Effects of Surface Modification on Biocompatibility of Magnesium Alloy WE42
10.3969/j.issn.0253-9896.2010.01.009
- VernacularTitle:表面修饰对镁合金WE42生物相容性的影响
- Author:
Lei ZHA
;
Yin LIU
;
Lu CAO
;
Jin ZHOU
- Publication Type:Journal Article
- Keywords:
alloys;
magnesium;
biocompatible materials;
materials testing;
microscopy;
electron;
scanning;
lactic acid;
umbilical veins;
endothelial cells
- From:
Tianjin Medical Journal
2010;38(1):26-28,后插1
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To evaluate the effects of micro-arc oxidation (MAO) and poly-L-lactic acid (PLLA) surface-modification on the biocompatibility of magnesium alloy WE42. Methods: Micro-arc oxidation surface-modificated WE42 (MAO/WE42) materials and MAO+PLLA surface-modificated WE42(MAO+PLLA/WE42) materials were prepared. The surface topography of materials in the physiological environment was observed in vitro by scanning electron microscopy. The human umbilical vein endothelial cells(HUVECs) were treated by leaching liquor of materials. The relative growth rate(RGR) was assessed by MTT assay to evaluate the level of cytotoxicity. The coagulation time(PT, RT) and hemolytic ratio were determined to evaluate the blood compatibility of those materials. Results: The observation of scanning electron microscopy indicated that WE42 corroded seriously after immersion. There were no obvious corrosion holes on the surface of MAO/WE42 and MAO+PLLA/WE42 materials after immersion. It was found that there were good anticoagulant properties but no apparent cytotoxicity in MAO/WE42 and MAO+PLLA/WE42 materials. The results of hemolysis test showed that there were lower hemolysis rates in MAO and MAO+PLLA materials than that of WE42. The material of MAO+PLLA possessed the better anti-hemolytic properties than that of MAO(P < 0.01). Conclusion: Micro-arc oxidation surface modification improved the biocompatibility of WE42. PLLA sealing treatment improved the anti-hemolytic performance of WE42. MAO+PLLA provided a safe drug-loading surface for drug-eluting stents of magnesium alloy.
