Effect of Membrane-coating on Dissolution and Stability of Sirolimus Dropping Pills
- VernacularTitle:薄膜包衣对西罗莫司滴丸溶出度及稳定性的影响研究
- Author:
Xianxi GUO
;
Wen HE
;
Shaoting LI
- Publication Type:Journal Article
- Keywords:
Sirolimus;
Dropping pills;
Membrane coating;
Dissolution;
Stability
- From:
China Pharmacist
2014;(11):1846-1848,1849
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the effect of membrane-coating on dissolution and stability of sirolimus ( SRL) dropping pills to prove the effect and rationality of the coating process. Methods:Opadry was used as the coating material for SRL dropping pills. Com-pared with those of uncoated SRL dropping pills, the dissolution and stability of membrane-coating SRL dropping pills were studied in vitro. Results:Compared with that of uncoated SRL dropping pills, the drug release amount of membrane-coating SRL dropping pills was lower (P<0. 05), however, the stable release rate showed no significant difference (P>0. 05). After the membrane-coating, the stability of SRL dropping pills was notable enhanced under high humidity (75% ± 5%) and strong light (4500lx ± 500lx) conditions, however, the stability showed no improved under high temperature(40℃ ± 2℃) condition. Conclusion: The membrane-coating can enhance the stability of SRL dropping pills without significant effect on drug release in vitro.
