Clinical application of detection of procalcitonin and high sensitivity C-reactive protein in the early diagnosis of bloodstream infection
10.3969/j.issn.1673-4130.2014.21.010
- VernacularTitle:降钙素原和超敏C反应蛋白定量检测在血流感染患者早期诊断中的应用
- Author:
Houlong LUO
;
Yan NONG
;
Zhichao MIU
;
Shan MO
;
Donghong LIU
;
Xingchao LIU
- Publication Type:Journal Article
- Keywords:
bloodstream infection;
procalcitonin;
hypersensitive C-reactive protein;
early diagnosis
- From:
International Journal of Laboratory Medicine
2014;(21):2887-2888,2890
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical value of detection of procalcitonin(PCT ) and high sensitivity C-reactive protein (hs-CRP) in early diagnosis of bloodstream infection(BSI) .Methods The serum levels of PCT and hs-CRP of 58 BSI patients(test group) and 58 non BSI patients(control group) were detected .The early diagnosis value of PCT and hs-CRP was evaluated by ROC curve .Results There were significant difference between the serum PCT and hs-CRP levels of test group and control group(P<0 .05) .The ROC AUC of PCT and hs-CRP were 0 .902(95% CI:0 .850-0 .955) and 0 .706(95% CI:0 .611-0 .801) ,respectively . With 2 .24 ng/mL being the diagnostic cut-off value ,the diagnostic sensitivity ,specificity ,positive predictive value ,and negative pre-dictive value of PCT were 77 .6% ,91 .4% ,90 .0% ,and 80 .3% ,respectively .With 64 .83 mg/L being the diagnostic cut-off value ,the di-agnostic sensitivity ,specificity ,positive predictive value ,and negative predictive value of hs-CRP were 74 .1% ,62 .1% ,54 .4% ,and 59 .5% , respectively .Conclusion Detection of serum PCT and hs-CRP has important clinical value in early diagnosis of BSI .
