Determination of Compound Proglumide Tablets by HPLC
- VernacularTitle:HPLC法测定复方丙谷胺片含量
- Author:
Bin WANG
;
Bixin YI
;
Changliang LI
- Publication Type:Journal Article
- Keywords:
HPLC;
Nitrogen determination method;
Proglumide
- From:
China Pharmacist
2014;(11):1967-1968,1969
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To establish an HPLC method for the determination of compound proglumide tablets. Methods:A Diamon-sil C18(250 mm ×4.6 mm,5 μm)column was used. The mobile phase was 2% ammonium acetate-methanol (40∶60), the detection wavelength was 225nm, and an external standard method was employed. Results:The linear range of proglumide was 2. 60-208. 10 μg (r=0. 999 9), and the average recovery was 99. 8%(n=6,RSD=0. 6%). Conclusion: The HPLC determination method for com-pound proglumide tablets is accurate, simple and reproducible.
