Animal experiment study of silica nanoparticles labeled peptides with 125 I
- VernacularTitle:包裹125 I标记多肽的二氧化硅纳米颗粒的动物实验研究
- Author:
Fengxiu WANG
;
Jiafen WANG
;
Xiaowei LU
- Publication Type:Journal Article
- Keywords:
silica nanoparticles;
oral drug system;
protein and peptide
- From:
Chinese Journal of Biochemical Pharmaceutics
2014;37(7):66-68,71
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study whether the silica nanoparticles can be used as a biomacromolecular carrier of oral drugs.Methods Studyed the influence of the amount of calcium ions on nano silica nanoparticles morphology,the encapsulation rate of silica nanoparticles on proteins or peptides in the presence of different calcium ions,the situation of proteins or peptides released from silica nanoparticles,enzymolysis of protein packaged by silica, silica nanoparticles labeled peptides with 125 I released in mice.Results Experiments showed that the synthetic silica nanoparticles packaged with peptides could smoothly reach the small intestine through the gastric acid in mice, it had potential to be biomacromolecular carrier of oral drug. Conclusion Proteins or peptides is easy to release in alkaline condition,but release few in acidic condition of pH2 (PH of gastric acid).The silica nanoparticles prepared have the potential to be oral drug carrier.
