Diagnosis value of combined detection of AFP,AFP-L3,DKK1 in primary hepatic carcinoma
10.3969/j.issn.1673-4130.2014.20.019
- VernacularTitle:AFP、AFP-L3、DKK1联合检测对原发性肝癌的诊断价值
- Author:
Weibo BO
;
Jibao QIN
- Publication Type:Journal Article
- Keywords:
primary hepatic carcinoma;
AFP;
AFP-L3;
DKK1
- From:
International Journal of Laboratory Medicine
2014;(20):2765-2766,2768
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical significance of the single detection or the combination detection of 3 kinds of tumor marker alpha-fetoprotein(AFP),alpha-fetoprotein-L3(AFP-L3)and DKK1 for the diagnosis of primary hepatic carcinoma(PHC). Methods AFP,AFP-L3 and DKK1 in the PHC group,benign hepatic diseases group and control group were detected by adopting the ECLIA,affinity adsorption chromatography and ELISA methods respectively.The ratio of AFP-L3 in AFP was calculated.Re-sults In the single detection,the sensitivity of AFP,AFP-L3 and DKK1 was 60.9%,76.8% and 69.6% respectively and the speci-ficity was 88.7%,91.5% and 95.8% respectively.In the combination detection,the sensitivity and specificity were 91.3% and 87.3% respectively,the differences between the single detection and the combination detection had statistical significance (P <0. 05).Conclusion The combined examination of serum AFP,AFP-L3 and DKK1 can elevate the sensitivity and specificity,which is much better and more accurate for diagnosing PHC than most of traditional combination detection at present.
