The identification value of diffusion weighted imaging in different molecular subtypes for breast cancer classification
10.3969/j.issn.1002-1671.2015.06.012
- VernacularTitle:磁共振 DWI 对乳腺癌分子亚型的鉴别诊断应用价值
- Author:
Guanqiao JIN
;
Danke SU
;
Dianzhong LUO
;
Shaolü LAI
;
Ningbin LUO
;
Wei KAN
;
Xiangyang HUANG
;
Xianliu FANG
- Publication Type:Journal Article
- Keywords:
magnetic resonance imaging;
diffusion weighted imaging;
breast cancer;
molecular classification
- From:
Journal of Practical Radiology
2015;(6):929-932,941
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of diffusion weighted imaging (DWI)in identification of different molecular sub-types for breast cancer classifications.Methods All patients with breast cancer were divided into four subtypes groups by immuno-histochemistry results including Luminal A subtype,Luminal B subtype,HER2-over expressing (HER2-OE)subtype,and triple negative breast cancer (TNBC),respectively.The means of maximum,average,and minimum ADC of the lesions in all patients were recorded.The analysis of ANOVA and least significant difference test (LSD-t )were used for the statistical evaluation.Results There were significant differences in maximum ADC,average ADC,and minimum ADC among Luminal A subtype (n=21),Lu-minal B subtype (n=22),HER2-OE subtype (n=1 7)and TNBC subtype (n=12)groups (P =0.025,0.039 and 0.041,respec-tively).However,paired comparison in mean of maximum ADC,average ADC and minimum ADC by LSD-t multiple comparisons among Luminal A,Luminal B,HER2-OE and TNBC respectively were not significantly different.Conclusion DWI may be difficult to discriminate the molecular subtypes of breast cancer classification before surgery or biopsy.
