Analysis of correlation between glycosylated hemoglobin and immunologic function in patients with type 2 diabetes
10.3969/j.issn.1000-484X.2014.10.020
- VernacularTitle:糖化血红蛋白与2型糖尿病患者免疫功能改变的相关性分析
- Author:
Biling CHEN
;
Qingling TAN
;
Hui ZHANG
;
Ping YAO
- Publication Type:Journal Article
- Keywords:
Type 2 diabetes;
Glycosylated hemoglobin;
Cellular immunity;
Humoral immunity
- From:
Chinese Journal of Immunology
2014;(10):1393-1395,1400
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the correlation between the glycosylated hemoglobin and immunologic function in patients with type 2 diabetes.Methods:Clinical data of patients with type 2 diabetes received treatment at our hospital from 2011 to 2014 was analyzed (Group A) and also included the healthy control as Group B.Results:A total of 75 patients were analyzed,Group A 45 cases and Group B 30 cases.Group A had a higher level of glycosylated hemoglobin than that of Group B , the difference was statistically significant(8.12±3.45 vs 4.87±1.65;t=4.472,P<0.001).Group A patients had lower levels of IgA,IgM and CD4/CD8 when compared with Group B ,the difference was statistically significant ( P<0.05 ).Correlation analysis shown the glycosylated hemoglobin had significantly negative correlation with IgA ,IgM and CD4/CD8 ( P<0.05 ).Conclusion: Patients with type 2 diabetes have a low immune function which are related to high level of Glycosylated hemoglobin.
