Clinical significance of CXCL9 and IL-22 expression in peripheral blood of patients with psoriasis vulgaris

VernacularTitle:CXCL9、IL-22在寻常型白癜风患者外周血中的表达及其临床意义
Author: Xiaoyan YE ; Yongjiang DAI ; Bingxin MENG ; Huiming ZENG ; Yan DING
Publication Type:Journal Article
Keywords: vitiligo; interleukin-22; Chemokine
From: Chongqing Medicine 2014;(31):4225-4226,4229
CountryChina
Language:Chinese
Abstract: Objective To detect the expression level of CXCL9 and IL‐22 in peripheral blood of patients with vitiligo vulgaris and explore its role in the pathogenesis of vitiligo vulgaris .Methods The level of CXCL9 and IL‐22 in peripheral blood from 35 vit‐iligo patients (20 active cases and 15 stable cases) and 20 normal controls were measured by enzyme linked immunosorbent assay . Then ,we compared the differences in different groups and analyzed their correlation with ages ,duration ,psoriasis area and severity index (PASI) .Results The contents of CXCL9 and IL‐22 in active cases and stable cases were obviously higher than those in con‐trols respectively by statistical analysis ,there was significant difference (P< 0 .05) .The contents of CXCL9 and IL‐22 in active ca‐ses were obvious higher than those in stable cases ,there was significant difference(P< 0 .05) .Conclusion CXCL9 and IL‐22 may be involved in the pathogenesis of vitiligo vulgaris .