Behavioral effects of early-life social isolation on adult rats
10.7644/j.issn.1674-9960.2014.10.011
- VernacularTitle:幼年社会隔离对大鼠成年后行为表征的影响
- Author:
Shuling LI
;
Hui YAN
;
Zehui GONG
- Publication Type:Journal Article
- Keywords:
social isolation;
behavior;
animal model;
schizophrenia
- From:Military Medical Sciences
2014;(10):791-794,822
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate rats reared in social isolation as a model of behavioral symptoms of neurodevelop-mental psychiatric disorders including schizophrenia.Methods Male rat pups were housed in individual cages from post-weaning to adulthood.Locomotor activity detection, Morris water maze test and social interaction test were performed. Results Compared with controls, the social isolation-reared rats got more body mass, showed locomotor hyperactivity and increased social interaction, but significant spatial learning changes were not observed in Morris water maze test.Conclu-sion Exposing rats to social isolation can profoundly affect behavior in adulthood, which can be used to build animal mod-els of neurodevelopmental psychiatric disorders including schizophrenia.
