Correlative research of HPV infection and the disease progression of cervical intraepithelial neoplasia

VernacularTitle:人乳头瘤病毒感染与宫颈上皮内瘤变疾病进展的相关性研究
Author: Lin MOU ; Ya HU ; Yin LAN ; Fenglin LV
Publication Type:Journal Article
Keywords: papillomavirus; cervical intraepithelial neoplasia; disease progression
From: Chongqing Medicine 2014;(29):3895-3896,3900
CountryChina
Language:Chinese
Abstract: Objective To investigate the HPV infection influence on the disease evolution of cervical intraepithelial neoplasia (CIN) .Methods 120 CIN grade Ⅰ patients diagnosed by under colposcopic biopsy pathology in 324th Hospital of PLA obstetrics and gynecology clinic from January to December 2010 were selected as the research objects ,concentrations of cervical secretions'HPV DNA were detected by hybrid capture two generations(HC-Ⅱ) of quantitative method .According to HPV infection ,patients were divided into CIN Ⅰ + HPV(-) and CIN Ⅰ + HPV(+ ) group and followed up for 3 years to obseve the disease evolution of CIN by means of TCT test and HR-HPV test .Results 13 .33% patients appeared disease progression in the CIN Ⅰ + HPV (-) group ,while 21 .67% in the CIN Ⅰ + HPV(+ ) group ,the difference between the two groups had significantly statistical difference (P<0 .05) .Conclusion HPV infection has an important role in the disease progression of CIN ,suggesting that the prevention and treatment of the HPV infection could slow down the progression of CIN .