Research on application of BuChE assess prehospital acute organophosphorus pesticide poisoning and the prognosis of patients with the disease
10.3969/j.issn.1671-8348.2014.30.016
- VernacularTitle:丁酰胆碱酯酶活性评估院前急性有机磷农药中毒患者病情及预后的应用研究
- Author:
Xiaoyong FAN
- Publication Type:Journal Article
- Keywords:
butyrylcholinesterase;
first aid;
poisoning;
risk assessment;
prognosis
- From:
Chongqing Medicine
2014;(30):4028-4029,4033
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the evaluation for condition and prognosis of butyrylcholinesterase(BuChE)evaluation for acute organophosphorus pesticide poisoning (AOPP) .Methods 110 cases of AOPP patients were collected ,venous blood of all the patients in pre-hospital was sampled for determination of BuChE activity ,and treatment lasted for 60 d ,then BuChE characteristic curves and forecast indexs were analyzed .Results 24 cases died and 96 cases survived ,pre-hospital BuChE activity of the death group was (36 .7 ± 34 .2)% ,and the survival group was (67 .2 ± 15 .4)% ,there was significant difference between the two groups (P<0 .05) .That BuChE activity≤30% of normal value in ROC curve was the optimal cut-off point to determine the AOPP poi-soning .Among 27 cases of patients ,who BuChE activity ≤30% of normal value ,the death rate was 74 .07% (20/27) ,among 93 cases of patients ,who BuChE activity>30% of normal value ,the death rate was 4 .30% (8/93) ,there was significant difference between the two groups(P<0 .01) .When the optimal cut-off point of BuChE activity was≤30% of normal value in pre-hospital patients with critical AOPP ,the specific degree of its death prediction was 0 .954 ,sensitivity was 0 .761 ,positive predictive value was 0 .825 ,accuracy was 0 .912 ,Youden index was 0 .716 .Conclusion BuChE activity is a rapid and effective predicted value for the AOPP ,it is worthy of clinical application .
