Association of HSP70 gene polymorphisms with type 2 diabetes mellitus in Hui and Han people in Ningxia
10.7644/j.issn.1674-9960.2014.09.016
- VernacularTitle:HSP70基因多态性与宁夏回汉民族2型糖尿病的关联研究
- Author:
Xiujuan TAO
;
Lin SONG
;
Yan QIANG
;
Chuan ZHAO
;
Yang YANG
;
Hui SONG
- Publication Type:Journal Article
- Keywords:
diabetes mellitus,type 2;
HSP70 heat shock proteins;
gene polymorphism;
polymerase chain reaction;
pol-ymorphism,restriction fragment length;
Hui nationality;
Han nationality
- From:Military Medical Sciences
2014;(9):719-723,728
- CountryChina
- Language:Chinese
-
Abstract:
Results There was no significant difference in the distribution of genotypes and allele frequencies of HSP 70-1 and HSP70-hom between case group and control group (P>0.05), but there was significant difference in the distribution of genotypes and allele frequencies of HSP70-2 between the two groups(P<0.05).There was no significant difference in the distribution of genotypes and allele frequencies of HSP70-1,HSP70-2 and HSP70-hom between Hui and Han people (P>0.05)or in the distribution of genotypes of HSP 70-2 between males and females in case group, but there was significant difference in the distribution of allele frequencies of HSP 70-2 in case group .There was no significant difference in the distribution of genotypes and allele frequencies of HSP 70-1 and HSP70-hom between males and females in case or control group .Logistic analysis confirmed that the WC, TG, TC, LDL-C, SBP, family history of diabetes and G allele were risk factors of T 2DM. Conclusion GG genotype and G allele of HSP 70-2 (+1267 ) SNP may be genetic markers for the susceptibility of type 2 diabetes.There is no significant difference in the distribution of genotypes and allele frequencies of HSP 70-1,HSP70-2 and HSP70-hom between Hui and Han nationalities .Family history of diabetes, LDL-C, TC, and G allele of HSP70-2 (+1267) SNP are the main risk factors of T2DM while HDL-C is a protective factor.
