The clinical efficacy of ilaprazole in the treatment of duodenal bulb ulcer

VernacularTitle:艾普拉唑治疗十二指肠球部溃疡的疗效观察
Author: Binming CHEN ; Anna GUO ; Suzuan CHEN ; Jing YU ; Xubin JING ; Guanghua GUO
Publication Type:Journal Article
Keywords: Duodenal ulcer; Helicobacter pylori; Ilaprazole; Omeprazole
From: Chinese Journal of Primary Medicine and Pharmacy 2014;(22):3381-3382,3383
CountryChina
Language:Chinese
Abstract: Objective To compare the clinical efficacy of ilaprazole standard triple therapy with omeprazole standard triple therapy in the treatment of patients with Helicobacter pylori ( Hp ) positive duodenal bulb ulcer. Methods 100 patients with Hp positive duodenal bulb ulcer were randomly divided into the two groups by lottery, given ilaprazole standard triple therapy and omeprazole standard triple therapy respectively.After 5 weeks of the course,take gastroscopy and the enzyme 13C-urea breath test,and the Hp eradication rate,clinical efficacy,ulcer heal-ing rate and adverse reactions were observed.Results The Hp eradication rate is better than the omeprazole group (92%vs 78%,χ2 =3.853,P<0.05),while the ulcer healing rate were no significant (96%vs 90%,χ2 =1.561, P>0.05).Conclusion It is a good method in the treatment of Hp positive duodenal bulb ulcer for ilaprazole stand-ard triple therapy.