Curative effect observation of labetalol combined with magnesium sulfate in treating moderate and severe pregnancy-induced hypertension disease
10.3760/cma.j.issn.1008-6706.2014.22.039
- VernacularTitle:拉贝洛尔联合硫酸镁治疗中重度妊娠期高血压疾病疗效观察
- Author:
Tongming YANG
- Publication Type:Journal Article
- Keywords:
Pregnancy-induced hypertension disease;
Labetalol;
Magnesium sulfate
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;(22):3455-3457,3458
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical effect and safety of labetalol combined with magnesium sulfate in treating moderate and severe pregnancy-induced hypertension disease.Methods 78 cases with moderate and severe pregnancy-induced hypertension disease were divided into the control group and observation group according to random number table method,39 cases were in each group.The patients in the control group were given the magnesi-um sulfate only,and the patients in the observation group were given the treatment of labetalol combined with magnesi-um sulfate.After treatment,the average blood pressure,24h urine protein,maternal heart rate,fetus heart rate and pregnancy outcomes were detected.Results After treatment,the average blood pressure[(134.5 ±9.7) vs (85.7 ± 5.9)]mmHg of observation group was significantly lower than the control group(t=4.60,7.21,all P<0.05);the 24h urine protein,maternal heart rate and fetus heart rate had no significant difference (t=0.52,0.56,0.15,all P>0.05);the termination of pregnancy(7.7%),placental abruption(0.0%),fetal distress(5.1%),incidence of neo-natal asphyxia(7.7%),postpartum hemorrhage(12.8%),low birth weight(12.8%) were significantly lower than the control group(33.3%,12.8%,20.5%,25.6%,33.3%,35.9%) (χ2 =7.86,5.34,4.13,4.52,4.62,5.64,all P<0.05);the total effective rate of observation group with 37 cases (94.9%) was significantly higher than the con-trol group with 31 cases (79.5%) (χ2 =4.13,P<0.05);the incidence of adverse reactions of observation group with 15.4%was significantly lower than the control group with 35.9%(χ2 =4.30,P<0.05).Conclusion Labe-talol combined with magnesium sulfate in treating moderate and severe pregnancy-induced hypertension disease could effectively reduce the average blood pressure,the 24h urine protein and improve the pregnancy outcomes,which was worthy of clinical popularization and application.
