Comparison of the effects of two therapeutic regimen in the treatment of idiopathic membranous nephropathy
10.3760/cma.j.issn.1008-6706.2014.21.015
- VernacularTitle:两种方案治疗特发性膜性肾病的疗效比较
- Author:
Beibei DING
- Publication Type:Journal Article
- Keywords:
Glomerulonephritis,Membranous;
Cyclophosphamide;
Cyclosporine A
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;(21):3238-3240,3241
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the clinical efficacy and safety between cyclosporine A combined with low-dose hormone and progestin hormone combined cyclophosphamide( CTX) in the treatment of idiopathic membra-nous nephropathy( IMN) .Methods 42 patients with IMN were randomly divided into group A and group B according to a random number table,21 cases in each group.On the same basic treatment,group A was given adequate glucocor-ticoid and CTX therapy,group B was given small doses of hormones combined with CsA.24hUpro,CR,ALT,ALB and GLU of the two groups at before treatment and 3 months,6 months,12 months after treatment were compared.And the complete remission rate,partial remission rate, relapse rate and adverse reactions in the two groups were also com-pared.Results The indicators of the two groups before treatment showed no significant difference,and 24hUpro of group A was (5.3 ±2.1)g/L,ALB was (21.8 ±8.1)g/L,while 24hUpro of group B was (5.4 ±2.3)g/L,ALB was (20.3 ±7.5)g/L,and 3 months of treatment,24hUpro was significantly decreased significantly and ALB increased in the two groups,24hUpro of group A was (3.2 ±1.2)g/L,ALB was (27.9 ±7.6)g/L,24hUpro of group B was (3.5 ± 1.3)g/L,ALB was (26.4 ±8.1)g/L.24hUpro showed a gradual downward trend(F=5.216,P<0.05),ALB showed a gradual upward trend(F=5.864,P<0.05).At different time points,the overall response rate between the two groups was no significant difference(P>0.05).The recurrence rate was 9.5% in group A,group B recurrence rate was 14.3%,which has no significant difference(P>0.05).The occurrence rate of adverse reactions of group A was 23.8 %and 28.6%in group,the difference between the two groups was not statistically significant(P>0.05). Conclusion The treatment of progestin hormone combined CTX has similar efficacy with CsA,and in clinical treat-ment,develop individualized treatment programs can be chosen according to the specific circumstances of the patients.
