Changes and significance of insulin-like growth factor-1 in infant myocarditis

VernacularTitle:心肌炎患儿血清胰岛素样生长因子-1水平变化及意义
Author: Yanyan LIANG ; Hua ZHU ; Shaofei YU
Publication Type:Journal Article
Keywords: Myocarditis; Insulin-like growth factor Ⅰ; Child
From: Chinese Journal of Primary Medicine and Pharmacy 2014;(22):3371-3372,3373
CountryChina
Language:Chinese
Abstract: Objective To investigate insulin-like growth factor-1(IGF-1) on the protective effect of infant myocarditis.Methods The serum levels of IGF-1 was detected by two-site enzyme-linked immunosorbent assy ( ELISA) and CK-MB by electrochemiluminescence at the acute and convalescent in 50 infant with myocarditis,and 50 normal healthy children as the controls.Results The serum levels of IGF-1 in acute myocarditis was significantly lower than those of healthy children and the convalescen[(22.90 ±9.30) mg/L vs (45.69 ±10.95) mg/L, (38.99 ±9.06)mg/L,all P<0.01],while the CK-MB was significantly higher than those of the control group and the convalescent[(77.48 ±8.71)mg/L vs (14.99 ±7.62)mg/L,(17.99 ±6.31)mg/L,all P<0.01.IGF-1 and CK-MB was negative correlation (r=-0.62,P<0.01).Conclusion IGF-1 is involved in the repair process of myocardial injury in myocarditis infant,and play some protective role in the mechanism.