Improving effects of dammarane sapogenins on sleep interruption-induced learning and memory impairment in mice
10.3969/j.issn.1671.7856.2014.010.009
- VernacularTitle:达玛烷苷元对睡眠干扰所致小鼠学习记忆障碍的改善作用
- Author:
Lanlan BU
;
Zhe SHI
;
Hongwei WU
;
Cong LU
;
Kezhu WANG
;
Yinghui LI
;
Lina QU
;
Xinmin LIU
- Publication Type:Journal Article
- Keywords:
Dammarane sapogenins;
Rotating drum test;
Sleep Interruption;
ICR mice;
Spontanous activity;
Morris water maze test;
Step-through test
- From:
Chinese Journal of Comparative Medicine
2014;(10):48-53,66
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of dammarane sapogenins ( DS-1226 ) on sleep interruption-induced learning and memory impairment in mice.Methods 130 SPF healthy 5 -6-week old male ICR mice were randomly divided into control, model, DS-1226 low dose, DS-1226 medium dose and DS-1226 high dose groups.The behavioral alterations in open field (OF), Morris water maze (MWM) and step-through (ST) tests were detected at 15 days after rotating drum-induced sleep interruption ( SI) .Results The total distance, movement speed, total duration of movement were increased in OF test ( P<0.05, vs.the model group) after treatment.The latency of place navigation was increased from day 5 in the MWM test after 15 d sleep interruption, and the number of crossing in the target quadrant and the percent distance in target quadrant were decreased after 15 d sleep interruption ( P <0.05, vs.the control group), while the latency of place navigation was decreased, and the percent distance in target quadrant and percent time in target quadrant after high dose DS-1226 oral administration ( P<0.05, vs.the model group) were increased.Error times, distance in dark chamber, time in dark chamber and immobility time in dark chamber were increased in training of step through test ( P<0.05, vs.the control group);while these indexes were decreased after DS-1226 oral administration ( P<0.05, vs.the model group) .But there was no significant difference in the step through testing course.Conclusions The results show that orally administrated DS-1226 can ameliorate SI-induced learning and memory impairment, and there is a significant dosage-effect relationship.
