Analysis of Factors That Affect Plasma D-Dimmer Level in Acute Aortic Syndrome
10.3969/j.issn.0253-9896.2014.10.013
- VernacularTitle:急性主动脉综合征患者血浆D-二聚体水平影响因素分析
- Author:
Qianyu GUO
;
Chengzhi LU
;
Dasheng XIA
- Publication Type:Journal Article
- Keywords:
D dimmer;
acute aortic syndrome;
aortic dissection;
aortic intramural hematoma
- From:
Tianjin Medical Journal
2014;(10):1005-1007,1008
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the factors that could affect plasma level of D-dimmer test in acute aortic syn-drome. Methods Blood samples (2 mL) from acute aortic syndrome patients (n=76) obtained immediately after admission to detect D-dimmer using ELISA. Blood routine test and biochemical indicators tests including creatinine were also performed. White blood cell (WBC), serum value of creatinine, aortic contrast-enhanced CT, incidence of Shock and death were all re-corded. The receiver-operating characteristic curve (ROC) was established to assess the potency of D-dimmer to predict hospital mortality. Results According to ROC analysis, the optimal cut-off value of D-dimmer to predict hospital mortality was >2 988.6 μg/L (FEU), with 86.7% sensitivity and 70.5% specificity. The patients were divided into group A (D-dim-mer<2 988.6μg/L FEU, n=45) and group B (D-dimmer≥2 988.6μg/L FEU,n=31). Onset timing was longer in group A than that in group B(P<0.01). Involvement of ascending aorta was less common in group A than in group B(P<0.05). Aortic intramural hematoma was less common in group A than in group B(P<0.05). Logistic analysis demonstrated that short time of onset, involvement of ascending aorta, non-aortic intramural hematoma were all independent factors of higher D-dimmer (≥2 988.6μg/L FEU). Conclusion Patients with long time of onset, without involvement of ascending aorta, with intramural hematoma are liable to have lower values of plasma D-dimmer.
