Expression and Clinical Significance of Neuropilin-1 and 2 in Colorectal Carcinoma
10.3969/j.issn.0253-9896.2014.10.011
- VernacularTitle:神经纤毛蛋白1、2在大肠癌组织中的表达及意义
- Author:
Weiguo XU
;
Na MIAO
;
Hong SUN
;
Yun LIU
;
Shiwei ZHANG
;
Xiaohui HAO
- Publication Type:Journal Article
- Keywords:
colorectal neoplasms;
neuropilins;
immunohistochemistry;
colorectal cancer;
micro vessel density;
tu-mor angiogenesis;
vascular endothelial cell
- From:
Tianjin Medical Journal
2014;(10):998-1001,1059
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the expression of Neuropilin (NRP)-1, 2, to calculate micro vessel density (MVD) in colorectal cancer, paraneoplastic tissues, normal tissues, and to investigate the correlation between NRP-1, 2 and MVD to understand the role of NRP-1, 2 in the process of tumor angiogenesis. Methods Expression of NRP-1 and NRP-2 were studied by immunohistochemistry in 66 specimens from colorectal cancer, paraneoplastic tissues and normal tissues. MVD was assessed based on CD105 immunohistochical staining. Results (1) The positive expression of NRP-1, 2 in colorectal cancer, paraneoplastic tissues, normal tissues were 71.2%, 25.8%, 0;80.3%, 15.2%, 0 respectively. There was a statistical difference between them (P<0.05). (2)The quantity of MVD in colorectal cancer, paraneoplastic tissues and normal tissues were 35.682±5.542, 14.485±3.301 and 6.864±1.771 respectively. There was a statistical difference between them (P<0.05). (3) Expression of NRP-1, 2 had a good correlation with the tumor size, infiltrating depth, lymph node metastasis, Dukes stag-ing (P<0.05), but no correlation was found with the tumor position, histological types, differentiation degree and the gender or age of patients (P>0.05). (4) The MVD value had no correlation with the gender or age of patients, tumor size, position, histological types (P>0.05), but had a good correlation with infiltrating depth, lymphatic metastasis and Dukes staging (P<0.05). (5) There was a positive correlation between NRP-1, 2 and MVD value (P<0.01). Conclusion NRP-1, 2 may play an important role in the angiogenesis of the colorectal cancer, and it correlates with the invasion and metastasis of colorectal cancer closely.
