Significance of combined detection of serum tumor markers in the diagnosis of NSCLC
10.3969/j.issn.1673-4130.2014.19.029
- VernacularTitle:肿瘤标志物联合检测在非小细胞肺癌诊断中的应用价值
- Author:
Fei MENG
;
Heng WANG
;
Xin LIANG
- Publication Type:Journal Article
- Keywords:
tumor marker;
combined detection;
non-small-cell lung cancer
- From:
International Journal of Laboratory Medicine
2014;(19):2638-2639,2643
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the diagnostic significance of combined detection of neuron specific enolase (NSE ) , cytokeratin 19 fragment(CYFRA21-1) ,carcinoembryonic antigen(CEA) ,carbohydrate antigen 125(CA125) ,carbohydrate antigen 19-9(CA19-9) and serum ferritin(SF) in non-small-cell lung cancer(NSCLC) .Methods NSE ,CYFRA21-1 ,CEA ,CA125 ,CA19-9 and SF were detected by chemiluminescent immunoassay in 52 patients with NSCLC(NSCLC group) ,35 patients with benign lung diseases(benign lung diseases group) and 44 healthy controls(control group) .Results These serum tumor markers in NSCLC group were significantly higher than those in benign lung diseases group and control group(P<0 .01) .Serum level of CEA was ob-viously higher ,while CYFRA21-1 was lower in patients with adenocarcinoma than those in patients with squamous carcinoma(P<0 .05) .The sensitivity(96 .2% ) ,specificity(87 .3% ) and accuracy(90 .8% ) of combined detection of these tumor markers preceded any single ones .Conclusion The combined detection of NSE ,CYFRA21-1 ,CEA ,CA125 ,CA19-9 and SF can improve the diagnos-tic sensitivity and accuracy of NSCLC ,which could provide higher clinical value in the diagnosis of NSCLC .
