Relationship between nuclear morphometrical quantitative analysis and clinicopathological features of breast cancer
10.13315/j.cnki.cjcep.2014.09.002
- VernacularTitle:乳腺癌细胞核形态定量分析与临床病理特征的关系
- Author:
Jian WANG
;
Gang MENG
;
Xiaodie ZHOU
- Publication Type:Journal Article
- Keywords:
breast neoplasm;
quantitative pathology;
prognosis
- From:
Chinese Journal of Clinical and Experimental Pathology
2014;(9):954-957,962
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To measure the nuclear morphological parameters of breast cancer to study the relationship between nuclear mor-phological parameters and ER, PR, HER-2 expression, and clinicopathologic features of breast carcinoma. Methods 388 cases of breast cancer specimens were collected and molecular classification was made according to ER, PR and HER-2 expression. the nucleus parameters were measured by image analysis software after HE staining. The difference among groups was statistically analysed, and follow-up was done by phone or by hospitalization. Results Among the 4 groups of breast cancer case, the differences of circle diame-ter, area and perimeter edges of the nucleus were statistically significant (P<0.05). Nuclear morphometric quantitation between ER+/PR+ patients and ER-/PR- patients was statistically significantly differentice (P<0.05). The majority of patients with ER-/PR- were histological gradeⅢand poor survival rate (P<0.05). The disease-free survival in Luminal A type was higher than that of Basal-like type (P<0.05), and its overall survival was higher than HER-2 over-expression (P<0. 05) and Basal-like type (P<0.05) . Conclusion The nucleus morphological quantitation in breast cancer is of significant difference, which has certain reference value in its molecular typing. The result of ER, PR and HER-2 expression, combined with nuclear morphology measurement, are meaningful to the treatment and assessment of prognosis.
