Meta analysis on the relationship between cuplike nuclei morphology and FLT3-ITD mutation in acute myeloid leukemia
10.3760/cma.j.issn.1009-9921.2012.02.010
- VernacularTitle:急性髓系白血病患者骨髓杯状核细胞阳性与FMS样酪氨酸激酶3基因内部串联重复突变相关性的Meta分析
- Author:
Qian ZHUANG
;
Liangchun HAO
;
Fang CHEN
;
Jihong ZHANG
- Publication Type:Journal Article
- Keywords:
Meta analysis;
Cuplike nuclei cell;
Leukemia,myeloid,acute;
FLT3-ITD mutation
- From:
Journal of Leukemia & Lymphoma
2012;21(2):98-100,104
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the association between cuplike nuclei morphology and FLT3-ITD mutation, so as to provide evidence for the minor classification of AML. MethodsThe articles on the association of cuplike nuclei morphology and FLT3-ITD mutation were retrieved by searching international and national databases from 1999 to 2011. The relationship was assessed by meta analysis with Statal 1 software.The OR value and confidence interval(CI)were calculated, and the publication bias was assessed by Begg test and Egger test.ResultsThere was significant difference between cuplike nuclei morphology appearance and FLT3-ITD mutation (OR =2.59,95 ％ CI 1.55-4.33,P =0.00).Results from both Begg' s test and Egger’ s test did not show significant difference indicating that there was no publication bias existed.ConclusionThe uncommon morphologic variant of AML with cuplike nuclei is highly associated with FLT3-ITD mutation, and the presence of cuplike nuclei in AML represents a distinctive morphologic finding that can be used to prioritize the molecular workup of patients with AML.
