Research Progress in Effects of Herbal Medicines on PXR and CAR Nuclear Receptor Pathways
- VernacularTitle:中草药对孕烷X受体和组成型雄烷受体等核受体通路影响的研究进展
- Author:
Weiyu CHANG
;
Huawen XIN
- Publication Type:Journal Article
- Keywords:
Chinese herbal medicines;
PXR;
CAR;
Drug interactions
- From:
China Pharmacist
2014;(12):2127-2130,2131
- CountryChina
- Language:Chinese
-
Abstract:
Pregnane X receptor ( PXR) , a member of the nuclear receptor subfamily, plays an important role in the regulation of drug metabolic enzymes and transporters. PXR can regulate the expression of downstream target genes through transforming a large number of exogenous and endogenous chemical substances, and can be activated by a variety of Chinese herbal medicines. The same as PXR, constitutive androstane receptor ( CAR) can participate in the regulation of drug metabolic enzyme CYP450 and become the targets of drug action through combining with exogenous ligands to regulate the expression of CYP2B6, CYP3A4, CYP2C19 and UGT1A1.
