Study on Relationship between Dopamine D1 Receptor Gene Polymorphisms and Clozapine Efficacy in Male Schizophrenic Patients
- VernacularTitle:男性精神分裂症患者服用氯氮平疗效与多巴胺D1受体基因多态性的相关性研究
- Author:
Ying CHEN
;
Na WU
;
Falin QU
;
Yuan WEI
;
Haiying YU
;
Guangjian WANG
;
Fangbin CHEN
- Publication Type:Journal Article
- Keywords:
Clozapine;
Schizophrenic;
Dopamine D1 receptor;
Gene polymorphisms
- From:
China Pharmacist
2014;(12):1993-1995,1996
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between dopamine D1 receptor ( DRD1 ) gene polymorphisms and clozapine efficacy in male schizophrenic patients. Methods:Totally 46 male schizophrenic patients were treated by clozapine for 6-8 weeks. The clinical response was determined by the Positive and Negative Symptom Scale (PANSS). DRD1 gene rs265981, rs5326, rs4532, rs1799914, rs686 and rs4867798 polymorphisms were detected by the gene sequencing, while plasma clozapine levels were monitored during the treatment. Results:The total clinical efficacy of clozapine response group and the non-response group was compared, the distribution of rs265981 genotype TT, TC and CC and allele T and C had statistically significant differences (P=0. 025;P=0. 005), and the distribution of rs686 genotype CC, CT and TC and allele C and T had statistically significant differences ( P=0. 044;P=0. 010). The negative symptom of the response group was compared with that of the non-response group, the distribution of rs4532 gen-otype GG, GA and AA and allele G and A had statistically significant differences (P=0. 034; P=0. 013). Conclusion: The poly-morphisms of DRD1 gene rs265981 and rs686 may have influence on the clinical efficacy of clozapine, and rs4532 may have influence on the negative symptom.
