Effects of Telmisartan on Insulin Resistance and Oxidative Stress in Nonalcoholic Steatohepatitis Rats
10.3969/j.issn.0253-9896.2014.12.011
- VernacularTitle:替米沙坦对非酒精性脂肪性肝炎大鼠胰岛素抵抗及氧化应激的影响
- Author:
Yingli LIU
;
Qiuzan ZHANG
;
Yanrong WANG
;
Qian YANG
;
Lina FU
;
Jing ZHANG
- Publication Type:Journal Article
- Keywords:
oxidative stress;
rats,Sprague-Dawley;
telmisartan;
polyene phosphatidylcholine;
nonalcoholic steato-hepatitis;
insulin resistance
- From:
Tianjin Medical Journal
2014;(12):1189-1192,1250
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of telmisartan on insulin resistance and oxidative stress in nonalco?holic steatohepatitis (NASH) rats. Methods Fifty male SD rats were randomly divided into five groups:control group, mod?el group, polyene phosphatidylcholine group, low-dose telmisartan group and high-dose telmisartan group by using random number table (n=10 in each group). Control group was given standard food,the other groups were given high fat diet for 12 weeks to establish NASH rat model. Then intervention groups were given either normal saline 1.0 mL/(kg·d) or polyene phos?phatidylcholine 8.4 mg/(kg·d), or telmisartan 4 mg/(kg·d) or telmisartan 8 mg/(kg·d) for 4 weeks by intragastric adminstra?tion. All rats were sacrificed at the end of the 16th week, the lever of plasma insulin resistance index (HOMA-IR), ALT, AST, TG, TC, MDA, SOD, T-AOC, CAT, GSH-PX and liver homogenate MDA, SOD, GSH-PX and liver NAS scores were tested. Results In polyene phosphatidylcholine treated group, the lever of plasma ALT, AST, HOMA-IR and liver NAS scores were degreased significantly compared with model group. The lever of plasma AST, SOD, T-AOC, CAT, GSH-PX and liver homogenate SOD, GSH-PX, liver NAS scores were improved in both low-dose and high-dose telmisartan groups com?pared with model group while plasma and liver homogenate MDA , HOMA-IR were reduced significantly in these two groups compared with model group. Besides, plasma ALT was significantly improved in high-dose telmisartan group compared with model group. Conclusion Telmisartan reduce plasma ALT, AST, oxidative stress, HOMA-IR and liver NAS scores in NASH rats. And high-does telmisartan is better than low-dose telmisartan and polyene phosphatidylcholine in treatment ef?fect.
