Research progress of lysophosphatidylcholines for liver diseases
10.3969/j.issn.1001-1978.2014.12.005
- VernacularTitle:溶血磷脂酰胆碱在肝脏疾病中的研究进展
- Author:
Danjun SONG
;
Jiaqi PAN
;
Pengxu LI
;
Zanbo CHU
;
Da FENG
;
Aiming LIU
;
Julin YANG
- Publication Type:Journal Article
- Keywords:
lysophosphatidylcholines;
liver diseases;
hepatic injury;
hepatotoxicity;
biomarker;
metabolite
- From:
Chinese Pharmacological Bulletin
2014;(12):1642-1645,1646
- CountryChina
- Language:Chinese
-
Abstract:
Lysophosphatidylcholines belong to a group of lipid components which have a variety of physiological functions. LPCs are known to be linked to metabolic disorders and cardio-vascular diseases,including diabetes,atherosclerosis and dyslip-idemia.LPCs are actively metabolized in liver,which is closely related with liver diseases and hepatotoxicity.The role of LPCs in liver diseases and hepatotoxicities has been extensively investi-gated recently.This review focuses on lysophosphatidylcholines as a biomarker for liver diseases,such as hepatic carcinoma, cholestasis,cirrhosis,hepatitis,and chemical hepatotoxicities, trying to lay a basis for investigation and therapeutics of liver dis-eases.
