Gucocorticoid receptor:a potential target for depression treatment
10.7644/j.issn.1674-9960.2014.11.017
- VernacularTitle:糖皮质激素受体：抑郁症治疗的潜在靶标
- Author:
Lei AN
;
Jing LI
;
Youzhi ZHANG
;
Yunfeng LI
- Publication Type:Journal Article
- Keywords:
glucocorticoid receptor;
depression;
HPA axis;
monoamine neurotransmitter;
antidepressant
- From:
Military Medical Sciences
2014;(11):908-911,917
- CountryChina
- Language:Chinese
-
Abstract:
Depression is a serious mental disorder characterized by lasting anhedonia and anorexia .The pathophysiology of depression is complicated , which is related to many neuroendocrine disturbances .Increased levels of glucocorticoid hor-mones and hyperactivity of the hypothalamus pituitary adrenal ( HPA) axis are the most consistent and typical pathophysio-logical alternations in patients with major depression , which are possibly caused by altered functions of the receptor of glu-cocorticoid hormones , the glucocorticoid receptor ( GR) .Promoting the expression and function of GR and restoring the im-paired feedback inhibition of the HPA axis seem to be particularly important for the therapeutic efficacy of antidepressants . In this review, the role of GR in the development and resolution of depression is discussed .
