Progress in modulation of T-type calcium channels by ;G protein-coupled receptors
10.3969/j.issn.1001-1978.2014.12.002
- VernacularTitle:G蛋白偶联受体对T型钙通道调节机制的研究进展
- Author:
Sha HUANG
;
Dongyang HUNAG
;
Hailin ZHANG
- Publication Type:Journal Article
- Keywords:
T-type calcium channels;
Cav3.1;
Cav3.2;
Cav3.3;
βγsubunits;
GPCRs;
modulation
- From:
Chinese Pharmacological Bulletin
2014;(12):1632-1634,1635
- CountryChina
- Language:Chinese
-
Abstract:
T-type calcium channels are expressed in various tis-sues and play key roles in physiology and pathophysiology,inclu-ding neuronal firing,hormone secretion,pain,and cancer,etc. Hence,it is critical to understand the molecular mechanisms un-derlying the regulation of T-type channels.Substantial literature suggests many G protein-coupled receptors (GPCRs)and related second messengers can modulate T-type channel in some extent. Here,this review focuses on the modulation of T-type calcium channels by GPCRs and related second messengers.
