Clinical value of serum PCT and CRP combination detection in diagnosis of liver cirrhosis complicating spontaneous bacterial peritonitis
10.3969/j.issn.1673-4130.2014.23.009
- VernacularTitle:血清降钙素原及C-反应蛋白的联合检测在肝硬化合并自发性细菌性腹膜炎诊断中的临床价值
- Author:
Ling HUANG
;
Jing HUANG
;
Ling YU
;
Dunnian XIA
;
Xiping GONG
- Publication Type:Journal Article
- Keywords:
liver cirrhosis;
spontaneous bacterial peritonitis;
procalcitonin;
C-reactive protein;
combination detection
- From:
International Journal of Laboratory Medicine
2014;(23):3176-3177,3179
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical value of serum procalcitonin(PCT)and C-reactive protein(CRP)combination detec-tion in early diagnosis of liver cirrhosis complicating spontaneous bacterial peritonitis(SBP).Methods The peripheral blood sam-ples were collected from 30 cases of liver cirrhosis complicating SBP,30 cases of simple ascites liver cirrhosis (non-SBP)and 45 healthy subjects as control group.The serum PCT level was detected by the dry immunofluorescence quantitation method and the serum CRP level was detected by the immunoturbidimetry.The sensitivity and specificity of PCT,CRP and PCT combined with CRP in diagnosing liver cirrhosis complicating SBP were compared and the relationship between PCT levels and prognosis was ana-lyzed.Results Compare with the healthy control group and the non-SBP group,the serum PCT and CRP levels in the SBP group were markedly increased(P <0.05).The sensitivity of PCT,CRP and PCT combined with CRP in diagnosing liver cirrhosis compli-cating SBP was 93.3%,90.0% and 96.6% respectively,and the specificity was 90.0%,75.0% and 95.0% respectively.Conclusion The combination detection of serum PCT and CRP can increase the sensitivity and specificity of the diagnosis and has more clini-cal value in early diagnosing liver cirrhosis complicating SBP.
