Study on application of determination of bone metabolic biochemical indexes in early diagnosis of middle and old age osteoporosis
10.3969/j.issn.1673-4130.2014.23.013
- VernacularTitle:骨代谢生化指标测定在中老年骨质疏松症早期诊断中的应用研究
- Author:
Rong GU
- Publication Type:Journal Article
- Keywords:
bone metabolic markers;
middle and old age;
osteoporosis;
early diagnosis
- From:
International Journal of Laboratory Medicine
2014;(23):3185-3186,3189
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the application value of determining the levels of biochemical indexes of bone metabolism in the early diagnosis of middle and old age osteoporosis.Methods 241 middle and old aged individuals undergoing the physical exami-nation in the health management center of our hospital from October 2012 to October 2013 were selected,determined the bone min-eral density(BMD)of the lumbar spine and divided into the normal bone mass group(n=66),osteopenia group(n=58),osteoporosis group(n= 63 )and severe osteoporosis group(n =54)according to the different BMD.The serum levels of bone-specific alkaline phosphatase(B-ALP),insulin-like growth factor-1(IGF-1)and tartrate-resistant acid phosphatase 5b(TRACP5b)were detected.The detection values of biochemical markers of bone metabolism in the four groups were statistically analyzed.Results There were sta-tistically significant differences in the serum levels of TRACP5b,B-ALP and IGF-1 among the four groups(P <0.05).The serum levels of TRACP5b,B-ALP and IGF-1 also had statistically significant differences between the osteopenia group,osteoporosis group and severe osteoporosis group with the normal bone mass group too(P <0.05);the serum levels of TRACP5b and B-ALP were in-creased with the decrease of bone mass(P <0.05),while the serum level of IGF-1 was decreased with the decrease of bone mass(P<0.05).Conclusion Detecting the serum levels of TRACP5b,B-ALP and IGF-1 is conducive to the early diagnosis of middle and old age primary osteoporosis.
