Effect of Chuanmingshen violaceum polysaccharides and its sulfated derivatives on immunosuppression induced by cyclophosphamide in mice
10.3969/j.issn.1000-484X.2015.01.011
- VernacularTitle:川明参多糖及其硫酸化物对免疫低下小鼠的影响
- Author:
Xinghong ZHAO
;
Zhongqiong YIN
;
Renyong JIA
;
Xingfang ZHAO
;
Xu SONG
;
Jiao XU
;
Li LI
;
Shujun DAI
;
Shuai KAN
;
Zhengwen LI
;
Lianci PENG
;
Zhenzhen CHEN
;
Zhiqiang HU
- Publication Type:Journal Article
- Keywords:
Chuanmingshen violaceum polysaccharides;
Solfated Chuanmingshen violaceum polysaccharides;
Immuno-suppression;
Immune organs indexes;
Spleen lymphocytes proliferation;
Cytokines
- From:
Chinese Journal of Immunology
2015;(1):52-55,60
- CountryChina
- Language:Chinese
-
Abstract:
Objective:In oder to investigate the effect of Chuanmingshen violaceum polysaccharides ( CVP) and Solfated Chua-nmingshen violaceum polysaccharides ( SCVP) on immunosuppression induced by cyclophosphamide ( CY) in mice.Methods: CY were used to induce immunosuppression in mice;Spleen and thymus indexes were used to evaluate the immune organs indexes;the [3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltet-razolium bromide,MTT] method was used to detect the proliferation of spleen lymphocytes of each group;the concentrations of IFN-γand IL-2 were assayed by ELISA kit.Results: SCVP and CVP could resist immunosuppression by promoting lymphocyte proliferation, increasing the contents of IFN-γ and IL-2, promoting immune organs development in immunosuppressive mice induced by CY.Conclusion:SCVP and CVP exhibited the potential to used as immunopotentiator.
