Study on diversity of pathological features induced by different phospholipid peptides in experimental autoimmune encephalomyelitis in Lewis rats
10.3969/j.issn.1000-484X.2015.01.023
- VernacularTitle:不同磷脂肽段诱导的实验性自身免疫性脑脊髓炎模型病理特征多样性的研究
- Author:
Meimei ZHENG
;
Yongjun WANG
;
Xinghu ZHANG
- Publication Type:Journal Article
- Keywords:
Myelin basic protein;
Myelin oligodendroglia glycoprotein;
Lewis rat;
Experimental autoimmune encephalomyelitis;
Pathological features
- From:
Chinese Journal of Immunology
2015;(1):109-113,121
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore whether different phospholipid peptides could induce different pathological features of EAE in Lewis rats.Methods:Lewis rats were immunized with myelin basic protein 82-99 (MBP82-99),MBP68-86,and myelin oligodendroglia glycoprotein 35-55 (MOG35-55),respectively,and evaluated everyday for neurological scores.The cerebrum,brain stem,cerebellum and spinal cord of every rat were removed and pathological features observed.Results: Rats immunized with the two MBP peptides exhibited neurological signs of EAE wherein the central nervous system had extensive inflammation infiltration.The number of infiltrates in spinal cords in the two MBP peptides groups was higher than that in the cerebrums,brain stems and cerebellums.In spinal cords, there was no statistical difference of infiltrates between MBP82-99 and MBP68-86 groups;however,the both groups had more infiltrates than MOG35-55 group.Inflammatory cells were observed only in spinal cords of animals immunized with MOG35-55.Conclusion:This study provides certain evidence for understanding the diversity of pathological manifestations of EAE in Lewis rats.
