Comparison of clinical therapeutic effect of sequential therapy and standard triple therapy for Helicobacter pylori
10.3760/cma.j.issn.1008-6706.2014.23.022
- VernacularTitle:序贯疗法与标准三联疗法治疗幽门螺杆菌的临床疗效比较
- Author:
Jian SUN
- Publication Type:Journal Article
- Keywords:
Sequential therapy;
Drug therapy,combination;
Helicobacter pylori
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;(23):3577-3578,3579
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical effects of sequential therapy and standard triple therapy for Helicobacter pylori.Methods 120 cases with positive Helicobacter pylori were divided into A group and B group according to the number table method,60 cases in each group.A group received sequential therapy ( omeprazole+amoxicillin treatment after 5 days continue to omeprazole clarithromycin and metronidazole treatment for 5 days),B group received standard triple therapy ( omeprazole +amoxicillin +clarithromycin ) , eradication rate of Helicobacter pylori,the total efficiency of ulcer healing and adverse reaction of the two groups were compared.Results The eradication rate of Helicobacter pylori of group A was 91.7%(55/60),which was significantly higher than 71.7%(43/60) of group B (χ2 =11.915,P=0.023);the ulcer healing and the total effective rate of group A was 96.7%(58/60),which was significantly higher than 88.3%(53/60) of group B,the difference was statistically significant (χ2 =9.915,P=0.038);there was no statistically significant difference between the two groups in adverse reaction (χ2 =4.735,P=0.072).Conclusion Sequential therapy has a better effect in treatment Helicobacter pylori than the standard triple therapy, which can significantly improve the eradication of Helicobacter pylori, with no serious adverse reactions.
