Expression and roles of the epithelial mesenchymal transition markers Vimentin and E-cadherin in craniopharyngioma
10.3969/j.issn.1671-8348.2014.33.008
- VernacularTitle:上皮间质转化标志物 Vimentin和 E-cadherin在颅咽管瘤中的表达及其临床意义
- Author:
Jie ZHOU
;
Chao ZHANG
;
Jun PAN
;
Ligang CHEN
;
Songtao QI
- Publication Type:Journal Article
- Keywords:
craniopharyngioma;
epithelial mesenchymal transition;
vimentin;
E-cadherin
- From:
Chongqing Medicine
2014;(33):4440-4443,4446
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the different protein expressions of epithelial mesenchymal transition (EM T ) markers Vimentin and E‐cadherin in craniopharyngioma ,especially at the tumour invasive front ,and correlate the findings with clinicopathological fea‐tures and patient outcomes .Methods Forty‐two craniopharyngiomas were subjected to the detection of Vimentin and E‐cadherin by immunohistochemistry and double immunofluorescence staining .The relationships between expression of these markers and various clinico pathological indicators and clinical outcomes of these tumors were analyzed .Results There was statistically significant difference in the expression of Vimentin and E‐cadherin between adamantinomatous and papillary variants in whole tumor and at the tumor invasive front .The expression of Vimentin and E‐cadherin in whole tumor sections were associated with tumor recurrence , postoperative weight and hypothalamic disturbances ,and the expression of vimentin and E‐cadherin at the tumor invasive front were colligated with tumor recurrence ,postoperative weight and hypothalamic disturbances .Conclusion Our study exemplifies the po‐tential prognostic implications of Vimentin and E‐cadherin expression in craniopharyngioma .EM T may represent a crucial mecha‐nism in the progression of adamantinomatous craniopharyngioma .
