Serum cartilage oligomeric matrix protein and relationship with vascular calcification in diabetic nephropathy patients
10.3969/j.issn.1671-8348.2014.32.015
- VernacularTitle:糖尿病肾病患者血清软骨寡聚基质蛋白水平及其与血管钙化的关系
- Author:
Conghui LIU
;
Xiuping JIN
- Publication Type:Journal Article
- Keywords:
diabetic nephropathy;
cardiovascular disease;
vascular calcification;
cartilage oligomeric matrix protein
- From:
Chongqing Medicine
2014;(32):4320-4321,4325
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the level of serum cartilage oligomeric matrix protein (COMP) and its relationship with vascular calcification in diabetic nephropathy (DN) patients .Methods COMP was tested in 54 (DN) group and 28 matched healthy persons (healthy group) .DN group was divided into vascular calcification group (VC) and non‐vascular calcification (non VC) group .DN group was also divided into cardiovascular disease group (CVD‐y) and without cardiovascular disease group (CVD‐n) in view of the company of cardiovascular disease .Serum COMP levels was compared between the DN group and the control group ,the VS group and the non VS group ,and the CVD‐y group and the CVD‐n group .The correlations between COMP level and the occur‐rence of cardiovascular disease ,the incidence of vascular calcification were estimated by Wald analysis of the application of Wald test .Results Serum COMP in DN group was significantly higher than the control group;Aortic arch calcification accounted for 75 .9% of the DN group .The serum COMP in VC group was higher than that of non VC group ,CVD‐y group had higher COMP than CVD‐n group old respectively with every 10 ng/mL increased in concentration of serum COMP .Conclusion The higher of concentration of serum COM P ,the more risk of vascular calcification and CVD .
